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Hybrid solution and solid-state NMR structure ensemble of phospholamban pentamer

Analyse Hybrid solution and solid-state NMR structure ensemble of phospholamban pentamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2KYV
Type: protein
Length: 260 residues
Chains: 5
Method: solution nmr; solid-state nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phospholamban
Pockets: 2 · best druggability 0.81

Structure

solution nmr; solid-state nmr · 1 distinct chain · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E	Phospholamban	protein	52	81% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	141	0.81	0.97	27	empty
2	96	0.75	0.94	25	empty

Interfaces

10 interfaces between chains.

D–E · 818 Å² buried · 13 hydrogen bonds · protein-protein
A–E · 818 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 817 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 816 Å² buried · 13 hydrogen bonds · protein-protein
B–C · 813 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

2KYV · Hybrid solution and solid-state NMR structure ensemble of phospholamban pentamer · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2KYV · PDBe 2KYV

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