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Dimeric human ckit-2 proto-oncogene promoter quadruplex DNA NMR, 10 structures

Analyse Dimeric human ckit-2 proto-oncogene promoter quadruplex DNA NMR, 10 structures in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2KYO
Type: DNA
Length: 42 nucleotides
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*GP*CP*GP*AP*GP*GP*GP*AP*GP *GP*GP*T)-3'
Pockets: 1 · best druggability 0.30

Structure

solution nmr · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	5'-D(CPGPGPGPCPGPGPGPCPGPCPGPAPGPGPGPAPGP GPGP*T)-3'	dna	21	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.30	0.74	12	empty

Interfaces

1 interface between chains.

A–B · 1466 Å² buried · 76 hydrogen bonds · nucleic-nucleic

Compared structures

2KYO · Dimeric human ckit-2 proto-oncogene promoter quadruplex DNA NMR, 10 structures · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2KYO · PDBe 2KYO

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