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Solution structure of human stem cell transcription factor nanog homeodomain fragment

Analyse Solution structure of human stem cell transcription factor nanog homeodomain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2KT0
Type
protein
Length
84 residues
Chains
1
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Homeobox protein nanog
UniProt
Q6NSW7
Pockets
2 · best druggability 0.47

Structure

solution nmr · 1 distinct chain · 43% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AHomeobox protein nanogprotein8443% helix, 0% strandQ6NSW7

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1690.470.8317empty
2950.370.7415empty

Compared structures

  • 2KT0 · Solution structure of human stem cell transcription factor Nanog homeodomain fragment · the same entry in another collection · chain A against A, TM-score 1.00
  • Q6NSW7 · AlphaFold monomer V2.0 prediction for homeobox protein NANOGP8 (Q6NSW7) · a predicted model of the same protein · chain A against A, TM-score 0.49

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