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Solution structure of the RBD1,2 domains from human nucleolin

Analyse Solution structure of the RBD1,2 domains from human nucleolin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2KRR
Type: protein
Length: 174 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleolin
UniProt: P19338
Pockets: 2 · best druggability 0.57

Structure

solution nmr · 1 distinct chain · 24% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleolin	protein	174	24% helix, 29% strand	P19338

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	351	0.57	0.75	26	empty
2	153	0.48	0.78	23	empty

Compared structures

2KRR · Solution structure of the RBD1,2 domains from human nucleolin · the same entry in another collection · chain A against A, TM-score 1.00
P19338 · AlphaFold monomer V2.0 prediction for nucleolin (P19338) · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19338
Elsewhere: RCSB PDB 2KRR · PDBe 2KRR · UniProt P19338

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