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Solution NMR structure of the homodimeric winged helix-turn-helix DNA- binding domain (fragment 1-100) MB0332 from mycobacterium bovis, a possible arsr-family transcriptional regulator. northeast structural genomics consortium target MBR242E.

Analyse Solution NMR structure of the homodimeric winged helix-turn-helix DNA- binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2KKO
Type: protein
Length: 216 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Possible transcriptional regulatory protein (possibly arsr- family)
UniProt: Q7U294
Pockets: 2 · best druggability 0.67

Structure

solution nmr · 1 distinct chain · 57% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Possible transcriptional regulatory protein (possibly arsr- family)	protein	108	57% helix, 13% strand	Q7U294

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.67	0.92	26	empty
2	88	0.48	0.82	16	empty

Interfaces

1 interface between chains.

A–B · 1284 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2KKO · Solution NMR structure of the homodimeric winged helix-turn-helix DNA-binding domain… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7U294
Elsewhere: RCSB PDB 2KKO · PDBe 2KKO · UniProt Q7U294

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