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Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone)

Analyse Structural basis for stabilization of the tau pre-mRNA splicing regulatory… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2KGP
Type
RNA
Length
25 nucleotides
Chains
1
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
RNA (25-mer)
Ligands
MIX

Structure

solution nmr · 1 distinct chain.

ChainMoleculeTypeResiduesSecondary structureUniProt
ARNA (25-mer)rna25——

Ligands and binding sites

  • MIX · 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl) amino]ethyl}amino)-9,10-anthracenedione · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 2KGP · Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by… · the same entry in another collection · chain A against A, TM-score 1.00

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