Research workbench
NMR structure of the cbp-TAZ1/STAT2-tad complex
Analyse NMR structure of the cbp-TAZ1/STAT2-tad complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2KA4
- Type
- protein
- Length
- 157 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Crebbp protein; Signal transducer and activator of transcription 2
- UniProt
- Q6GQV9, P52630
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.44
Structure
solution nmr · 2 distinct chains · 48% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Crebbp protein | protein | 100 | 58% helix, 0% strand | Q6GQV9 |
| B | Signal transducer and activator of transcription 2 | protein | 57 | 30% helix, 0% strand | P52630 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.44 | 0.82 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2379 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 2KA4 · NMR structure of the CBP-TAZ1/STAT2-TAD complex · the same entry in another collection · chain A against A, TM-score 1.00
- P52630 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 2… · a predicted model of the same protein · chain B against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GQV9
- Every structure of UniProt P52630
- Elsewhere: RCSB PDB 2KA4 · PDBe 2KA4 · UniProt Q6GQV9 · UniProt P52630
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