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Solution NMR structure of the filamin-migfilin complex

Analyse Solution NMR structure of the filamin-migfilin complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2K9U
Type: protein
Length: 143 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma filamin; Filamin-binding lim protein 1
UniProt: Q59H94, Q8WUP2
Pockets: 2 · best druggability 0.74

Structure

solution nmr · 2 distinct chains · 0% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gamma filamin	protein	119	0% helix, 40% strand	Q59H94
B	Filamin-binding lim protein 1	protein	24	0% helix, 33% strand	Q8WUP2

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.74	0.96	21	empty
2	131	0.50	0.79	27	empty

Interfaces

1 interface between chains.

A–B · 618 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

2K9U · Solution NMR structure of the Filamin-migfilin complex · the same entry in another collection · chain A against A, TM-score 1.00
Q8WUP2 · AlphaFold monomer V2.0 prediction for filamin-binding lim protein 1 (Q8WUP2) · a predicted model of the same protein · chain B against A, TM-score 0.22

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q59H94
Every structure of UniProt Q8WUP2
Elsewhere: RCSB PDB 2K9U · PDBe 2K9U · UniProt Q59H94 · UniProt Q8WUP2

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