Research workbench
NMR structure of the complex between TFB1 subunit of tfiih and the activation domain of VP16
Analyse NMR structure of the complex between TFB1 subunit of tfiih and the activation… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2K2U
- Type
- protein
- Length
- 150 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase II transcription factor B subunit 1; Alpha trans-inducing protein
- UniProt
- P32776, P04486
- Pockets
- 2 · best druggability 0.37
Structure
solution nmr · 2 distinct chains · 19% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase II transcription factor B subunit 1 | protein | 115 | 18% helix, 32% strand | P32776 |
| B | Alpha trans-inducing protein | protein | 35 | 20% helix, 0% strand | P04486 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 98 | 0.37 | 0.75 | 17 | empty |
| 2 | 81 | 0.32 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 536 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2K2U · NMR Structure of the complex between Tfb1 subunit of TFIIH and the activation domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- P32776 · AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih… · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32776
- Every structure of UniProt P04486
- Elsewhere: RCSB PDB 2K2U · PDBe 2K2U · UniProt P32776 · UniProt P04486
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