Research workbench
How the HIV-1 nucleocapsid protein binds and destabilises the (-) primer binding site during reverse transcription
Analyse How the HIV-1 nucleocapsid protein binds and destabilises the (-) primer… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2JZW
- Type
- protein + DNA
- Length
- 58 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HIV-1 nucleocapsid protein NCP7(12-55); DNA (5'…
- Ligands
- ZN
Structure
solution nmr · 2 distinct chains · 7% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HIV-1 nucleocapsid protein NCP7(12-55) | protein | 44 | 7% helix, 0% strand | — |
| B | DNA (5'- D(*DGP*DTP*DCP*DCP*DCP*DTP*DGP*DTP*DTP*DCP*DGP*DGP*DGP*DC)-3') | dna | 14 | — | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 892 Ų buried · 39 hydrogen bonds · protein-nucleic
Compared structures
- 2JZW · How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2JZW · PDBe 2JZW
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