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The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line

Analyse The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2JH8
Type: protein
Length: 613 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: VP4 core protein
UniProt: P07132
Ligands: GUN, M7G
Pockets: 7 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	VP4 core protein	protein	613	35% helix, 16% strand	P07132

Ligands and binding sites

GUN · Guanine · ligand · 2 copies · chains A
M7G · 7N-methyl-8-hydroguanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	99	0.71	0.94	29	empty
2	261	0.57	0.77	27	empty
3	292	0.57	0.76	34	empty
4	263	0.56	0.77	33	GUN
5	135	0.43	0.75	15	GUN

Compared structures

2JH8 · The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07132
Elsewhere: RCSB PDB 2JH8 · PDBe 2JH8 · UniProt P07132

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