Research workbench
Family 37 trehalase from escherichia COLI in complex with 1- thiatrehazolin
Analyse Family 37 trehalase from escherichia COLI in complex with 1- thiatrehazolin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2JG0
- Type
- protein
- Length
- 507 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Periplasmic trehalase
- EC
- 3.2.1.28
- UniProt
- P13482
- Ligands
- TTZ
- Pockets
- 4 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Periplasmic trehalase (EC 3.2.1.28) | protein | 507 | 50% helix, 9% strand | P13482 |
Ligands and binding sites
- TTZ · N-[(3aS,4R,5S,6S,6aS)-4,5,6-trihydroxy-4-(hydroxymethyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]thiazol-2-yl]-alpha- D-glucopyranosylamine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.78 | 0.99 | 25 | TTZ |
| 2 | 81 | 0.37 | 0.76 | 14 | empty |
| 3 | 65 | 0.30 | 0.74 | 18 | empty |
| 4 | 53 | 0.28 | 0.74 | 15 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2JG0 · Family 37 trehalase from Escherichia coli in complex with 1- thiatrehazolin · the same entry in another collection · chain A against A, TM-score 1.00
- P13482 · AlphaFold monomer V2.0 prediction for periplasmic trehalase (P13482) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13482
- Elsewhere: RCSB PDB 2JG0 · PDBe 2JG0 · UniProt P13482
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