Crystal structure of the zn-soaked ferritin from the hyperthermophilic archaeal anaerobe pyrococcus furiosus

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 1% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 72 copies · chains 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z
• FE · Fe (III) ion · metal · 36 copies · chains 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z
• SO4 · Sulfate ion · ion · 44 copies · chains 1, 2, 3, D, 4, 8, 5, 6, 0, 7, 9, A, C, B, E, G, U, Y, F, X, H, R, I, J, K, M, O, P, L, Q, S, T, V, W, Z

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Interfaces

93 interfaces between chains.

• 6–O · 1612 Ų buried · 21 hydrogen bonds · protein-protein
• C–U · 1605 Ų buried · 22 hydrogen bonds · protein-protein
• 3–L · 1602 Ų buried · 21 hydrogen bonds · protein-protein
• H–Z · 1595 Ų buried · 21 hydrogen bonds · protein-protein
• 2–K · 1592 Ų buried · 21 hydrogen bonds · protein-protein

Compared structures

• 2JD8 · Crystal Structure of the Zn-soaked Ferritin from the Hyperthermophilic Archaeal Anaerobe… · the same entry in another collection · chain 1 against 1, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8U2T8
• Elsewhere: RCSB PDB 2JD8 · PDBe 2JD8 · UniProt Q8U2T8