Crystal structure of the fe-soaked ferritin from the hyperthermophilic archaeal anaerobe pyrococcus furiosus

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 1% strand (DSSP).

Ligands and binding sites

• FE · Fe (III) ion · metal · 108 copies · chains 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z
• SO4 · Sulfate ion · ion · 26 copies · chains 1, 5, 2, 3, D, 8, 9, A, C, B, E, Y, G, U, I, J, H, K, O, R, S, X, T, V, W

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Interfaces

96 interfaces between chains.

• 6–O · 1609 Ų buried · 19 hydrogen bonds · protein-protein
• C–U · 1608 Ų buried · 22 hydrogen bonds · protein-protein
• 4–M · 1606 Ų buried · 23 hydrogen bonds · protein-protein
• 2–K · 1604 Ų buried · 25 hydrogen bonds · protein-protein
• D–V · 1594 Ų buried · 21 hydrogen bonds · protein-protein

Compared structures

• 2JD7 · Crystal Structure of the Fe-soaked Ferritin from the Hyperthermophilic Archaeal Anaerobe… · the same entry in another collection · chain 1 against 1, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8U2T8
• Elsewhere: RCSB PDB 2JD7 · PDBe 2JD7 · UniProt Q8U2T8