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The crystal structure of the natural F112L human sorcin mutant

Analyse The crystal structure of the natural F112L human sorcin mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2JC2
Type: protein
Length: 664 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sorcin
UniProt: P30626
Ligands: SO4
Pockets: 7 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Sorcin	protein	166	63% helix, 10% strand	P30626

Ligands and binding sites

SO4 · Sulfate ion · ion · 6 copies · chains A, C, B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	801	0.74	0.79	91	SO4
2	401	0.65	0.79	46	SO4
3	342	0.64	0.79	45	SO4
4	169	0.62	0.84	32	empty
5	281	0.61	0.79	31	SO4

Interfaces

6 interfaces between chains.

B–D · 2481 Å² buried · 28 hydrogen bonds · protein-protein
A–C · 2349 Å² buried · 30 hydrogen bonds · protein-protein
C–D · 1995 Å² buried · 38 hydrogen bonds · protein-protein
A–B · 1992 Å² buried · 38 hydrogen bonds · protein-protein
B–C · 144 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2JC2 · The crystal structure of the natural F112L human sorcin mutant · the same entry in another collection · chain A against A, TM-score 1.00
P30626 · AlphaFold monomer V2.0 prediction for sorcin (P30626) · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30626
Elsewhere: RCSB PDB 2JC2 · PDBe 2JC2 · UniProt P30626

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