Research workbench

Fxi apple 4 domain loop-out conformation

Analyse Fxi apple 4 domain loop-out conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2J8L
Type: protein
Length: 180 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Coagulation factor XI
EC: 3.4.21.27
UniProt: P03951
Pockets: 2 · best druggability 0.58

Structure

solution nmr · 1 distinct chain · 14% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Coagulation factor XI (EC 3.4.21.27)	protein	90	14% helix, 32% strand	P03951

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	260	0.58	0.78	37	empty
2	55	0.33	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 636 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

2J8L · FXI Apple 4 domain loop-out conformation · the same entry in another collection · chain A against A, TM-score 1.00
P03951 · AlphaFold monomer V2.0 prediction for coagulation factor XI (P03951) · a predicted model of the same protein · chain B against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03951
Elsewhere: RCSB PDB 2J8L · PDBe 2J8L · UniProt P03951

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.