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X-ray structure of the N-terminus rrm domain of SET1

Analyse X-ray structure of the N-terminus rrm domain of SET1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2J8A
Type: protein
Length: 114 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histone-lysine N-methyltransferase, H3 lysine-4 specific
EC: 2.1.1.43
UniProt: P38827
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.43)	protein	114	38% helix, 26% strand	P38827

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.44	0.80	14	empty

Compared structures

2J8A · X-ray structure of the N-terminus RRM domain of Set1 · the same entry in another collection · chain A against A, TM-score 1.00
P38827 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-4… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38827
Elsewhere: RCSB PDB 2J8A · PDBe 2J8A · UniProt P38827

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