Research workbench
Structural analysis of the PP2C family phosphatase tppha of thermosynechococcus elongatus
Analyse Structural analysis of the PP2C family phosphatase tppha of thermosynechococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2J86
- Type
- protein
- Length
- 471 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein serine-threonine phosphatase
- UniProt
- Q8DGS1
- Ligands
- MG
- Pockets
- 7 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein serine-threonine phosphatase | protein | 235 | 32% helix, 27% strand | Q8DGS1 |
| B | Protein serine-threonine phosphatase | protein | 236 | 36% helix, 27% strand | Q8DGS1 |
Ligands and binding sites
- MG · Magnesium ion · metal · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.59 | 0.89 | 24 | empty |
| 2 | 153 | 0.56 | 0.82 | 31 | empty |
| 3 | 224 | 0.44 | 0.72 | 31 | empty |
| 4 | 150 | 0.43 | 0.75 | 30 | MG |
| 5 | 53 | 0.39 | 0.81 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 27 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2J86 · Structural analysis of the PP2C Family Phosphatase tPphA of Thermosynechococcus elongatus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8DGS1
- Elsewhere: RCSB PDB 2J86 · PDBe 2J86 · UniProt Q8DGS1
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