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Crystal structure of recombinant human stromal cell-derived factor-1ALPHA

Analyse Crystal structure of recombinant human stromal cell-derived factor-1ALPHA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2J7Z
Type: protein
Length: 136 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Stromal cell-derived factor 1 alpha
UniProt: P48061
Pockets: 1 · best druggability 0.27

Structure

x-ray diffraction · 1 distinct chain · 18% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Stromal cell-derived factor 1 alpha	protein	68	18% helix, 25% strand	P48061

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	68	0.27	0.72	16	empty

Interfaces

1 interface between chains.

A–B · 1061 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2J7Z · Crystal Structure of recombinant Human Stromal Cell-Derived Factor- 1alpha · the same entry in another collection · chain A against A, TM-score 1.00
P48061 · AlphaFold monomer V2.0 prediction for stromal cell-derived factor 1 (P48061) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48061
Elsewhere: RCSB PDB 2J7Z · PDBe 2J7Z · UniProt P48061

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