Research workbench
Dcoh, a bifunctional protein-binding transcriptional coactivator
Analyse Dcoh, a bifunctional protein-binding transcriptional coactivator in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1DCO
- Type
- protein
- Length
- 792 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dcoh
- EC
- 4.2.1.96
- UniProt
- P61459
- Pockets
- 8 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Dcoh (EC 4.2.1.96) | protein | 99 | 47% helix, 21% strand | P61459 |
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.50 | 0.78 | 16 | empty |
| 2 | 187 | 0.49 | 0.76 | 20 | empty |
| 3 | 127 | 0.39 | 0.74 | 21 | empty |
| 4 | 63 | 0.31 | 0.75 | 13 | empty |
| 5 | 71 | 0.29 | 0.73 | 18 | empty |
Interfaces
14 interfaces between chains.
- C–D · 751 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 740 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 737 Ų buried · 9 hydrogen bonds · protein-protein
- G–H · 729 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 553 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1DCO · Dcoh, a bifunctional protein-binding transcriptional coactivator · the same entry in another collection · chain H against H, TM-score 1.00
- P61459 · AlphaFold monomer V2.0 prediction for pterin-4-alpha-carbinolamine dehydratase (P61459) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61459
- Elsewhere: RCSB PDB 1DCO · PDBe 1DCO · UniProt P61459
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