Research workbench
Crystal structure of encephalitozoon cuniculi TAF5 N- terminal domain
Analyse Crystal structure of encephalitozoon cuniculi TAF5 N- terminal domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2J4B
- Type
- protein
- Length
- 656 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 72/90-100 kda
- UniProt
- Q8SQS4
- Pockets
- 11 · best druggability 0.60
Structure
x-ray diffraction · 5 distinct chains · 74% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription initiation factor tfiid subunit 72/90-100 kda | protein | 129 | 74% helix, 9% strand | Q8SQS4 |
| B | Transcription initiation factor tfiid subunit 72/90-100 kda | protein | 133 | 73% helix, 9% strand | Q8SQS4 |
| C | Transcription initiation factor tfiid subunit 72/90-100 kda | protein | 133 | 70% helix, 9% strand | Q8SQS4 |
| D | Transcription initiation factor tfiid subunit 72/90-100 kda | protein | 131 | 76% helix, 9% strand | Q8SQS4 |
| E | Transcription initiation factor tfiid subunit 72/90-100 kda | protein | 130 | 76% helix, 9% strand | Q8SQS4 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 394 | 0.60 | 0.76 | 34 | empty |
| 2 | 321 | 0.54 | 0.74 | 34 | empty |
| 3 | 170 | 0.51 | 0.78 | 26 | empty |
| 4 | 134 | 0.47 | 0.78 | 22 | empty |
| 5 | 129 | 0.45 | 0.77 | 25 | empty |
Interfaces
4 interfaces between chains.
- A–E · 431 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 271 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 238 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 152 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2J4B · Crystal structure of Encephalitozoon cuniculi TAF5 N-terminal domain · the same entry in another collection · chain E against E, TM-score 1.00
- Q8SQS4 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 5… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8SQS4
- Elsewhere: RCSB PDB 2J4B · PDBe 2J4B · UniProt Q8SQS4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.