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Alpha-glucan recognition by family 41 carbohydrate-binding modules from streptococcal virulence factors

Analyse Alpha-glucan recognition by family 41 carbohydrate-binding modules from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2J43
Type: protein
Length: 437 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spydx
UniProt: Q99XX8
Pockets: 4 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Spydx	protein	219	5% helix, 41% strand	Q99XX8
B	Spydx	protein	218	5% helix, 41% strand	Q99XX8

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	202	0.47	0.75	25	empty
2	73	0.31	0.74	23	empty
3	57	0.30	0.75	14	empty
4	54	0.28	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 39 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

2J43 · Alpha-glucan recognition by family 41 carbohydrate-binding modules from streptococcal… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99XX8
Elsewhere: RCSB PDB 2J43 · PDBe 2J43 · UniProt Q99XX8

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