Research workbench
Molecular basis of akap specificity for PKA regulatory subunits
Analyse Molecular basis of akap specificity for PKA regulatory subunits in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2IZY
- Type
- protein
- Length
- 374 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase regulatory subunit II
- EC
- 2.7.11.11
- UniProt
- P12368
- Pockets
- 5 · best druggability 0.63
Structure
x-ray diffraction · 6 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent protein kinase regulatory subunit II (EC 2.7.11.11) | protein | 47 | 79% helix, 0% strand | P12368 |
| B | Camp-dependent protein kinase regulatory subunit II (EC 2.7.11.11) | protein | 46 | 76% helix, 0% strand | P12368 |
| C | Camp-dependent protein kinase regulatory subunit II (EC 2.7.11.11) | protein | 46 | 78% helix, 0% strand | P12368 |
| D, H | Camp-dependent protein kinase regulatory subunit II (EC 2.7.11.11) | protein | 47 | 77% helix, 0% strand | P12368 |
| E, F | Camp-dependent protein kinase regulatory subunit II (EC 2.7.11.11) | protein | 48 | 75% helix, 0% strand | P12368 |
| G | Camp-dependent protein kinase regulatory subunit II (EC 2.7.11.11) | protein | 45 | 78% helix, 0% strand | P12368 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 240 | 0.63 | 0.81 | 33 | empty |
| 2 | 234 | 0.57 | 0.79 | 33 | empty |
| 3 | 111 | 0.39 | 0.75 | 16 | empty |
| 4 | 94 | 0.37 | 0.75 | 14 | empty |
| 5 | 56 | 0.37 | 0.80 | 16 | empty |
Interfaces
14 interfaces between chains.
- E–F · 1058 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 1040 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1028 Ų buried · 11 hydrogen bonds · protein-protein
- G–H · 1027 Ų buried · 11 hydrogen bonds · protein-protein
- B–F · 879 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2IZY · Molecular Basis of AKAP Specificity for PKA Regulatory Subunits · the same entry in another collection · chain H against H, TM-score 1.00
- P12368 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type II-alpha… · a predicted model of the same protein · chain G against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12368
- Elsewhere: RCSB PDB 2IZY · PDBe 2IZY · UniProt P12368
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