Structure of casein kinase gamma 3 in complex with inhibitor

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 17% strand (DSSP).

Ligands and binding sites

• BRK · {(2Z)-4-amino-2-[(4-methoxyphenyl)imino]-2,3-dihydro-1,3-thiazol-5-yl}(4-methoxyphenyl)methanone · ligand · chains A
• MG · Magnesium ion · metal · 2 copies · chains A
• CL · Chloride ion · ion · 4 copies · chains A
• PGO · S-1,2-propanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Compared structures

• 2IZR · Structure of casein kinase gamma 3 in complex with inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y6M4 · AlphaFold monomer V2.0 prediction for casein kinase I isoform gamma-3 (Q9Y6M4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y6M4
• Elsewhere: RCSB PDB 2IZR · PDBe 2IZR · UniProt Q9Y6M4