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MS2-RNA hairpin (G-10) complex

Analyse MS2-RNA hairpin (G-10) complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2IZN
Type
protein + RNA
Length
413 residues
Chains
5
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
MS2 coat protein; 5'-R(*AP*CP*AP*UP*CP*GP*CP*GP*AP*UP *UP*AP*CP*GP*GP*AP*UP*GP*U)-3'
UniProt
P03612
Pockets
4 · best druggability 0.65

Structure

x-ray diffraction · 3 distinct chains · 19% helix, 48% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, B, CMS2 coat proteinprotein12919% helix, 48% strandP03612
R5'-R(*AP*CP*AP*UP*CP*GP*CP*GP*AP*UP *UP*AP*CP*GP*GP*AP*UP*GP*U)-3'rna15——
S5'-R(*AP*CP*AP*UP*CP*GP*CP*GP*AP*UP *UP*AP*CP*GP*GP*AP*UP*GP*U)-3'rna11——

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
13480.650.8036empty
24190.620.7743empty
34370.610.7551empty
4540.270.7412empty

Interfaces

6 interfaces between chains.

  • A–B · 3336 Ų buried · 45 hydrogen bonds · protein-protein
  • A–C · 519 Ų buried · 5 hydrogen bonds · protein-protein
  • B–R · 459 Ų buried · 16 hydrogen bonds · protein-nucleic
  • A–R · 416 Ų buried · 10 hydrogen bonds · protein-nucleic
  • C–S · 363 Ų buried · 9 hydrogen bonds · protein-nucleic

Compared structures

  • 2IZN · MS2-RNA hairpin (G-10) complex · the same entry in another collection · chain A against A, TM-score 1.00

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