Research workbench
MS2-RNA hairpin (4ONE -5) complex
Analyse MS2-RNA hairpin (4ONE -5) complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2IZ9
- Type
- protein + RNA
- Length
- 417 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MS2 coat protein; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*U onep *AP*CP*CP*CP*AP*UP*GP*U)-3'
- UniProt
- P03612
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 19% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | MS2 coat protein | protein | 129 | 19% helix, 47% strand | P03612 |
| R, S | 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*U onep *AP*CP*CP*CP*AP*UP*GP*U)-3' | rna | 15 | — | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 790 | 0.71 | 0.77 | 78 | empty |
| 2 | 221 | 0.44 | 0.73 | 20 | empty |
| 3 | 191 | 0.40 | 0.72 | 19 | empty |
| 4 | 77 | 0.32 | 0.72 | 12 | empty |
| 5 | 57 | 0.28 | 0.72 | 11 | empty |
Interfaces
4 interfaces between chains.
- A–C · 515 Ų buried · 5 hydrogen bonds · protein-protein
- A–R · 371 Ų buried · 7 hydrogen bonds · protein-nucleic
- C–S · 366 Ų buried · 9 hydrogen bonds · protein-nucleic
- C–R · 94 Ų buried · 1 hydrogen bond · protein-nucleic
Modifications
Observed in the structure: 2 modified (nucleotide modification).
Compared structures
- 2IZ9 · MS2-RNA hairpin (4ONE -5) complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03612
- Elsewhere: RCSB PDB 2IZ9 · PDBe 2IZ9 · UniProt P03612
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