Research workbench
Crystal structure of the PP2A phosphatase activator YPA1 PTPA1
Analyse Crystal structure of the PP2A phosphatase activator YPA1 PTPA1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2IXO
- Type
- protein
- Length
- 619 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 2A activator 1
- UniProt
- P40454
- Pockets
- 6 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 2A activator 1 | protein | 307 | 59% helix, 3% strand | P40454 |
| B | SERINE/THREONINE-protein phosphatase 2A activator 1 | protein | 312 | 58% helix, 3% strand | P40454 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 399 | 0.68 | 0.81 | 64 | empty |
| 2 | 268 | 0.59 | 0.79 | 43 | empty |
| 3 | 256 | 0.54 | 0.76 | 38 | empty |
| 4 | 174 | 0.44 | 0.74 | 27 | empty |
| 5 | 114 | 0.40 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 643 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2IXO · CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa1 PTPA1 · the same entry in another collection · chain A against A, TM-score 1.00
- P40454 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A activator 1… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40454
- Elsewhere: RCSB PDB 2IXO · PDBe 2IXO · UniProt P40454
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