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Origin binding domain of the SV40 large T antigen (residues 131-259). P212121 crystal form
Analyse Origin binding domain of the SV40 large T antigen (residues 131-259). P212121… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ITJ
- Type
- protein
- Length
- 246 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Large T antigen
- UniProt
- P03070
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Large T antigen | protein | 128 | 31% helix, 31% strand | P03070 |
| B | Large T antigen | protein | 118 | 28% helix, 34% strand | P03070 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.49 | 0.79 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 627 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2ITJ · Origin binding domain of the SV40 large T antigen (residues 131-259). P212121 crystal form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03070
- Elsewhere: RCSB PDB 2ITJ · PDBe 2ITJ · UniProt P03070
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