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Crystal structure of the polymerase domain from mycobacterium tuberculosis ligase D

Analyse Crystal structure of the polymerase domain from mycobacterium tuberculosis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IRU
Type: protein
Length: 568 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative DNA ligase-like protein RV0938/MT0965
EC: 2.7.7.-
UniProt: P71571
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative DNA ligase-like protein RV0938/MT0965 (EC 2.7.7.-)	protein	286	29% helix, 27% strand	P71571
B	Putative DNA ligase-like protein RV0938/MT0965 (EC 2.7.7.-)	protein	282	29% helix, 28% strand	P71571

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	338	0.62	0.78	38	empty
2	63	0.37	0.79	18	empty
3	92	0.33	0.74	22	empty
4	81	0.31	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 632 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

2IRU · Crystal Structure of the Polymerase Domain from Mycobacterium tuberculosis Ligase D · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P71571
Elsewhere: RCSB PDB 2IRU · PDBe 2IRU · UniProt P71571

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