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Crystal structure of T159D mutant of S. typhimurium phon protein

Analyse Crystal structure of T159D mutant of S. typhimurium phon protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IPB
Type: protein
Length: 876 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Class a nonspecific acid phosphatase phon
EC: 3.1.3.2
UniProt: Q71EB8
Pockets: 9 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Class a nonspecific acid phosphatase phon (EC 3.1.3.2)	protein	219	68% helix, 1% strand	Q71EB8

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	590	0.75	0.81	52	empty
2	61	0.68	0.95	25	empty
3	280	0.67	0.82	29	empty
4	282	0.65	0.81	30	empty
5	357	0.57	0.75	41	empty

Interfaces

3 interfaces between chains.

A–B · 1751 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 1736 Å² buried · 12 hydrogen bonds · protein-protein
A–D · 212 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2IPB · Crystal structure of T159D mutant of S. Typhimurium PhoN protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q71EB8
Elsewhere: RCSB PDB 2IPB · PDBe 2IPB · UniProt Q71EB8

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