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Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from escherichia COLI K12

Analyse Crystal structure of N-terminal truncated DNA-binding transcriptional dual… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IKS
Type: protein
Length: 547 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA-binding transcriptional dual regulator
Pockets: 5 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA-binding transcriptional dual regulator	protein	276	41% helix, 23% strand	—
B	DNA-binding transcriptional dual regulator	protein	271	41% helix, 23% strand	—

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	955	0.80	0.82	94	empty
2	85	0.56	0.86	17	empty
3	82	0.42	0.79	17	empty
4	82	0.39	0.77	11	empty
5	51	0.35	0.79	10	empty

Interfaces

1 interface between chains.

A–B · 1695 Å² buried · 32 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

2IKS · Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2IKS · PDBe 2IKS

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