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Crystal structure of aminopeptidase

Analyse Crystal structure of aminopeptidase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IJZ
Type: protein
Length: 4,548 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable M18-family aminopeptidase 2
EC: 3.4.11.-
UniProt: Q9HYZ3
Pockets: 20 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L	Probable M18-family aminopeptidase 2 (EC 3.4.11.-)	protein	379	14% helix, 18% strand	Q9HYZ3

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	929	0.83	0.84	81	empty
2	756	0.83	0.86	71	empty
3	890	0.82	0.84	137	empty
4	997	0.81	0.83	80	empty
5	1077	0.81	0.82	82	empty

Interfaces

18 interfaces between chains.

A–D · 3180 Å² buried · 36 hydrogen bonds · protein-protein
I–L · 3170 Å² buried · 33 hydrogen bonds · protein-protein
G–J · 3163 Å² buried · 33 hydrogen bonds · protein-protein
E–H · 3155 Å² buried · 35 hydrogen bonds · protein-protein
C–F · 3147 Å² buried · 38 hydrogen bonds · protein-protein

Compared structures

2IJZ · Crystal structure of aminopeptidase · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HYZ3
Elsewhere: RCSB PDB 2IJZ · PDBe 2IJZ · UniProt Q9HYZ3

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