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Crystal structure analysis of COLE1 rom mutant F14W

Analyse Crystal structure analysis of COLE1 rom mutant F14W in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IJH
Type: protein
Length: 171 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulatory protein rop
UniProt: P03051
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 89% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Regulatory protein rop	protein	57	89% helix, 0% strand	P03051

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	89	0.39	0.78	23	empty

Interfaces

2 interfaces between chains.

A–B · 1428 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 498 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

2IJH · Crystal structure analysis of ColE1 ROM mutant F14W · the same entry in another collection · chain A against A, TM-score 1.00
P03051 · AlphaFold monomer V2.0 prediction for regulatory protein rop (P03051) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03051
Elsewhere: RCSB PDB 2IJH · PDBe 2IJH · UniProt P03051

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