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Crystal structure of putative melanin biosynthesis protein tyra with bound heme (NP_716371.1) from shewanella oneidensis at 2.30 a resolution

Analyse Crystal structure of putative melanin biosynthesis protein tyra with bound heme… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IIZ
Type: protein
Length: 306 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Melanin biosynthesis protein tyra, putative
UniProt: Q8EIU4
Ligands: HEM, NA
Pockets: 2 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Melanin biosynthesis protein tyra, putative	protein	306	30% helix, 26% strand	Q8EIU4

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
NA · Sodium ion · metal · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A
IPA · Isopropyl alcohol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	337	0.81	0.90	44	HEM
2	146	0.60	0.85	25	empty

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

2IIZ · Crystal structure of putative melanin biosynthesis protein TyrA with bound heme… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt Q8EIU4
Elsewhere: RCSB PDB 2IIZ · PDBe 2IIZ · UniProt Q8EIU4

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