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Solution structure of the rous sarcoma virus nucleocapsid PROTEIN:UPSI RNA packaging signal complex

Analyse Solution structure of the rous sarcoma virus nucleocapsid PROTEIN:UPSI RNA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IHX
Type: protein + RNA
Length: 125 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Upsi RNA; Nucleocapsid (nc) protein
UniProt: P03322
Ligands: ZN
Pockets: 2 · best druggability 0.77

Structure

solution nmr · 2 distinct chains · 12% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Upsi RNA	rna	75	—	—
A	Nucleocapsid (nc) protein	protein	50	12% helix, 8% strand	P03322

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1052	0.77	0.80	62	empty
2	564	0.68	0.79	25	empty

Interfaces

1 interface between chains.

B–A · 1423 Å² buried · 24 hydrogen bonds · protein-nucleic

Compared structures

2IHX · Solution Structure of the Rous Sarcoma Virus Nucleocapsid Protein:uPsi RNA Packaging… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03322
Elsewhere: RCSB PDB 2IHX · PDBe 2IHX · UniProt P03322

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