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Structure of the N-wasp EVH1 domain in complex with an extended wip peptide

Analyse Structure of the N-wasp EVH1 domain in complex with an extended wip peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IFS
Type: protein
Length: 169 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wiskott-aldrich syndrome protein interacting protein and neural wiskott-aldrich syndrome…
UniProt: O43516, O08816
Pockets: 1 · best druggability 0.46

Structure

solution nmr · 1 distinct chain · 14% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wiskott-aldrich syndrome protein interacting protein and neural wiskott-aldrich syndrome protein chimera	protein	169	14% helix, 31% strand	O43516, O08816

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.46	0.78	22	empty

Compared structures

2IFS · Structure of the N-WASP EVH1 domain in complex with an extended WIP peptide · the same entry in another collection · chain A against A, TM-score 1.00
O08816 · AlphaFold monomer V2.0 prediction for neural wiskott-aldrich syndrome protein (O08816) · a predicted model of the same protein · chain A against A, TM-score 0.58
O43516 · AlphaFold monomer V2.0 prediction for WAS/WASL-interacting protein family member 1… · a predicted model of the same protein · chain A against A, TM-score 0.19

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43516
Every structure of UniProt O08816
Elsewhere: RCSB PDB 2IFS · PDBe 2IFS · UniProt O43516 · UniProt O08816

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