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Polyamines stabilize left-handed Z-DNA. we found new type of polyamine which stabilize left-handed Z-DNA by X-ray crystallography

Analyse Polyamines stabilize left-handed Z-DNA. we found new type of polyamine which… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2IE1
Type
DNA
Length
12 nucleotides
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DG)-3')
Ligands
PAW

Structure

x-ray diffraction · 1 distinct chain.

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BDNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DG)-3')dna6——

Ligands and binding sites

  • PAW · N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

  • A–B · 317 Ų buried · 28 hydrogen bonds · nucleic-nucleic

Compared structures

  • 2IE1 · Polyamines stabilize left-handed Z-DNA. We found new type of polyamine which stabilize… · the same entry in another collection · chain A against A, TM-score 1.00

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