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Crystal structure of translation initiation factor EIF4E from wheat

Analyse Crystal structure of translation initiation factor EIF4E from wheat in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IDR
Type: protein
Length: 354 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 4E-1
UniProt: P29557
Pockets: 3 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Eukaryotic translation initiation factor 4E-1	protein	177	28% helix, 32% strand	P29557

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	302	0.57	0.77	40	empty
2	277	0.56	0.77	32	empty
3	69	0.46	0.83	22	empty

Interfaces

1 interface between chains.

A–B · 1285 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2IDR · Crystal structure of translation initiation factor EIF4E from wheat · the same entry in another collection · chain A against A, TM-score 1.00
P29557 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-1… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29557
Elsewhere: RCSB PDB 2IDR · PDBe 2IDR · UniProt P29557

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