Research workbench
Crystal structure of a conserved protein of unknown function SP1372 from streptococcus pneumoniae
Analyse Crystal structure of a conserved protein of unknown function SP1372 from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2IAZ
- Type
- protein
- Length
- 441 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein SP1372
- UniProt
- Q97Q59
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 3 distinct chains · 85% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical protein SP1372 | protein | 108 | 84% helix, 0% strand | Q97Q59 |
| B, D | Hypothetical protein SP1372 | protein | 113 | 85% helix, 0% strand | Q97Q59 |
| C | Hypothetical protein SP1372 | protein | 107 | 87% helix, 0% strand | Q97Q59 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 531 | 0.60 | 0.74 | 45 | empty |
| 2 | 281 | 0.59 | 0.78 | 25 | empty |
| 3 | 219 | 0.49 | 0.75 | 29 | empty |
Interfaces
6 interfaces between chains.
- B–D · 1770 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 1560 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 1271 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 1245 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 313 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 modified (engineered).
Compared structures
- 2IAZ · Crystal structure of a Conserved Protein of Unknown Function SP1372 from Streptococcus… · the same entry in another collection · chain A against A, TM-score 1.00
- Q97Q59 · AlphaFold monomer V2.0 prediction for UPF0342 protein SP_1372 (Q97Q59) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97Q59
- Elsewhere: RCSB PDB 2IAZ · PDBe 2IAZ · UniProt Q97Q59
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