Research workbench
Transcriptional regulatory protein PF0864 from pyrococcus furiosus a member of the asnc family (PF0864)
Analyse Transcriptional regulatory protein PF0864 from pyrococcus furiosus a member of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2IA0
- Type
- protein
- Length
- 309 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative hth-type transcriptional regulator PF0864
- UniProt
- Q8U2H1
- Ligands
- AU
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative hth-type transcriptional regulator PF0864 | protein | 156 | 40% helix, 28% strand | Q8U2H1 |
| B | Putative hth-type transcriptional regulator PF0864 | protein | 153 | 43% helix, 29% strand | Q8U2H1 |
Ligands and binding sites
- AU · Gold ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.71 | 0.96 | 17 | empty |
| 2 | 126 | 0.42 | 0.76 | 17 | empty |
| 3 | 160 | 0.42 | 0.74 | 27 | empty |
| 4 | 112 | 0.39 | 0.75 | 24 | empty |
| 5 | 76 | 0.32 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2911 Ų buried · 57 hydrogen bonds · protein-protein
Compared structures
- 2IA0 · Transcriptional Regulatory Protein PF0864 From Pyrococcus Furiosus a Member of the ASNC… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8U2H1 · AlphaFold monomer V2.0 prediction for uncharacterized hth-type transcriptional regulator… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8U2H1
- Elsewhere: RCSB PDB 2IA0 · PDBe 2IA0 · UniProt Q8U2H1
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