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NMR solution structure of human EPHRINB2 ectodomain

Analyse NMR solution structure of human EPHRINB2 ectodomain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2I85
Type: protein
Length: 142 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ephrin-B2
UniProt: P52799
Pockets: 1 · best druggability 0.76

Structure

solution nmr · 1 distinct chain · 6% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ephrin-B2	protein	142	6% helix, 30% strand	P52799

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	654	0.76	0.81	61	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2I85 · NMR solution structure of Human ephrinB2 ectodomain · the same entry in another collection · chain A against A, TM-score 1.00
P52799 · AlphaFold monomer V2.0 prediction for ephrin-B2 (P52799) · a predicted model of the same protein · chain A against A, TM-score 0.67

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52799
Elsewhere: RCSB PDB 2I85 · PDBe 2I85 · UniProt P52799

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