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Hyaluronan-binding domain of CD44 in its ligand-bound form

Analyse Hyaluronan-binding domain of CD44 in its ligand-bound form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2I83
Type: protein
Length: 158 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CD44 antigen
UniProt: P16070
Pockets: 1 · best druggability 0.55

Structure

solution nmr · 1 distinct chain · 12% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CD44 antigen	protein	158	12% helix, 22% strand	P16070

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.55	0.80	30	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

2I83 · hyaluronan-binding domain of CD44 in its ligand-bound form · the same entry in another collection · chain A against A, TM-score 1.00
P16070 · AlphaFold monomer V2.0 prediction for CD44 antigen (P16070) · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16070
Elsewhere: RCSB PDB 2I83 · PDBe 2I83 · UniProt P16070

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