Research workbench
Crystal structure of E. COLI hype, a hydrogenase maturation protein
Analyse Crystal structure of E. COLI hype, a hydrogenase maturation protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2I6R
- Type
- protein
- Length
- 1,274 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hype protein
- UniProt
- Q7ABB2
- Pockets
- 11 · best druggability 0.81
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hype protein | protein | 316 | 34% helix, 26% strand | Q7ABB2 |
| B | Hype protein | protein | 315 | 36% helix, 26% strand | Q7ABB2 |
| C | Hype protein | protein | 321 | 34% helix, 26% strand | Q7ABB2 |
| D | Hype protein | protein | 322 | 35% helix, 26% strand | Q7ABB2 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 730 | 0.81 | 0.84 | 74 | empty |
| 2 | 1111 | 0.80 | 0.81 | 103 | empty |
| 3 | 743 | 0.79 | 0.83 | 77 | empty |
| 4 | 783 | 0.77 | 0.81 | 75 | empty |
| 5 | 716 | 0.76 | 0.81 | 76 | empty |
Interfaces
3 interfaces between chains.
- C–D · 2748 Ų buried · 44 hydrogen bonds · protein-protein
- A–B · 2668 Ų buried · 46 hydrogen bonds · protein-protein
- B–D · 607 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2I6R · Crystal structure of E. coli HypE, a hydrogenase maturation protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7ABB2
- Elsewhere: RCSB PDB 2I6R · PDBe 2I6R · UniProt Q7ABB2
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