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Receiver domain from myxococcus xanthus social motility protein frzs

Analyse Receiver domain from myxococcus xanthus social motility protein frzs in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2I6F
Type: protein
Length: 363 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Response regulator frzs
Ligands: CL
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 43% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Response regulator frzs	protein	124	42% helix, 21% strand	—
B	Response regulator frzs	protein	121	43% helix, 21% strand	—
C	Response regulator frzs	protein	118	44% helix, 22% strand	—

Ligands and binding sites

CL · Chloride ion · ion · 4 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.71	0.98	17	empty
2	382	0.62	0.77	34	empty
3	196	0.49	0.76	34	CL
4	76	0.43	0.81	14	empty

Interfaces

2 interfaces between chains.

A–C · 419 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 364 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

2I6F · Receiver domain from Myxococcus xanthus social motility protein FrzS · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2I6F · PDBe 2I6F

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