Research workbench
Engineering the ptpbeta catalytic domain with improved crystallization properties
Analyse Engineering the ptpbeta catalytic domain with improved crystallization… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2I5X
- Type
- protein
- Length
- 561 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase beta
- EC
- 3.1.3.48
- UniProt
- P23467
- Ligands
- UA5, MG, CL
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase beta (EC 3.1.3.48) | protein | 280 | 38% helix, 22% strand | P23467 |
| B | Receptor-type tyrosine-protein phosphatase beta (EC 3.1.3.48) | protein | 281 | 40% helix, 22% strand | P23467 |
Ligands and binding sites
- UA5 · (4-ethylphenyl)sulfamic acid · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · chains B
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 87 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2I5X · Engineering the PTPbeta catalytic domain with improved crystallization properties · the same entry in another collection · chain A against A, TM-score 1.00
- P23467 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase beta… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23467
- Elsewhere: RCSB PDB 2I5X · PDBe 2I5X · UniProt P23467
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