Research workbench

Crystal structures of a poxviral glutaredoxin in the oxidized and reduced states show redox-correlated structural changes

Analyse Crystal structures of a poxviral glutaredoxin in the oxidized and reduced… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2HZF
Type: protein
Length: 219 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutaredoxin-1
EC: 1.8.5.1
UniProt: Q8JLF5
Pockets: 2 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutaredoxin-1 (EC 1.8.5.1)	protein	110	43% helix, 18% strand	Q8JLF5
B	Glutaredoxin-1 (EC 1.8.5.1)	protein	109	43% helix, 18% strand	Q8JLF5

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	299	0.54	0.75	40	empty
2	62	0.38	0.79	13	empty

Interfaces

1 interface between chains.

A–B · 307 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2HZF · Crystal structures of a poxviral glutaredoxin in the oxidized and reduced states show… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8JLF5
Elsewhere: RCSB PDB 2HZF · PDBe 2HZF · UniProt Q8JLF5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.