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Structure of the transcriptional regulator SCO7222, a tetr from streptomyces coelicolor

Analyse Structure of the transcriptional regulator SCO7222, a tetr from streptomyces… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2HXO
Type: protein
Length: 414 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative tetr-family transcriptional regulator
UniProt: Q9K463
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative tetr-family transcriptional regulator	protein	207	73% helix, 0% strand	Q9K463
B	Putative tetr-family transcriptional regulator	protein	207	75% helix, 0% strand	Q9K463

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	147	0.81	0.97	28	empty
2	171	0.80	0.96	26	empty
3	290	0.65	0.81	42	empty
4	96	0.36	0.75	27	empty
5	58	0.32	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 2518 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

2HXO · Structure of the transcriptional regulator SCO7222, a TetR from Streptomyces coelicolor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9K463
Elsewhere: RCSB PDB 2HXO · PDBe 2HXO · UniProt Q9K463

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