Research workbench
Structure of a atypical orphan response regulator protein revealed a new phosphorylation-independent regulatory mechanism
Analyse Structure of a atypical orphan response regulator protein revealed a new… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2HQR
- Type
- protein
- Length
- 446 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative transcriptional regulator
- UniProt
- Q9ZM42
- Pockets
- 11 · best druggability 0.75
Structure
solution nmr · 1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Putative transcriptional regulator | protein | 223 | 39% helix, 21% strand | Q9ZM42 |
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.75 | 0.90 | 30 | empty |
| 2 | 668 | 0.70 | 0.78 | 66 | empty |
| 3 | 62 | 0.68 | 0.95 | 17 | empty |
| 4 | 149 | 0.64 | 0.86 | 29 | empty |
| 5 | 308 | 0.62 | 0.79 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 703 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2HQR · Structure of a Atypical Orphan Response Regulator Protein Revealed a New… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ZM42
- Elsewhere: RCSB PDB 2HQR · PDBe 2HQR · UniProt Q9ZM42
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