Research workbench
Structure of a atypical orphan response regulator protein revealed a new phosphorylation-independent regulatory mechanism
Analyse Structure of a atypical orphan response regulator protein revealed a new… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2HQO
- Type
- protein
- Length
- 238 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative transcriptional regulator
- UniProt
- Q9ZM42
- Pockets
- 2 · best druggability 0.61
Structure
solution nmr · 1 distinct chain · 43% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Putative transcriptional regulator | protein | 119 | 43% helix, 20% strand | Q9ZM42 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.61 | 0.90 | 22 | empty |
| 2 | 291 | 0.53 | 0.75 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 962 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2HQO · Structure of a Atypical Orphan Response Regulator Protein Revealed a New… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ZM42
- Elsewhere: RCSB PDB 2HQO · PDBe 2HQO · UniProt Q9ZM42
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