Research workbench
Crystal structure of the F91STOP mutant of DES1-6 bovine neurophysin- I, unliganded state
Analyse Crystal structure of the F91STOP mutant of DES1-6 bovine neurophysin- I… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2HNW
- Type
- protein
- Length
- 400 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Oxytocin-neurophysin 1
- UniProt
- P01175
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Oxytocin-neurophysin 1 | protein | 80 | 11% helix, 30% strand | P01175 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.72 | 0.96 | 26 | empty |
| 2 | 110 | 0.59 | 0.86 | 25 | empty |
| 3 | 117 | 0.49 | 0.80 | 21 | empty |
| 4 | 126 | 0.46 | 0.78 | 21 | empty |
| 5 | 102 | 0.45 | 0.79 | 18 | empty |
Interfaces
7 interfaces between chains.
- C–D · 546 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 544 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 475 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 443 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 321 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 35 disulfide (disulfide).
Compared structures
- 2HNW · Crystal Structure of the F91STOP mutant of des1-6 Bovine Neurophysin-I, unliganded state · the same entry in another collection · chain A against A, TM-score 1.00
- P01175 · AlphaFold monomer V2.0 prediction for oxytocin-neurophysin 1 (P01175) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01175
- Elsewhere: RCSB PDB 2HNW · PDBe 2HNW · UniProt P01175
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